Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278021 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL4278016 | 1.00 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL18837529 | 0.88 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL3695188 | 0.88 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL4930922 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL27651927 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL1285890 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL743064 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL1285869 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL103927 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-05-28 | — | — | US | disclosed |
| US-4629740-A | ENANTIOMORPHS OF 4-AMINO-N/1-PHENYLETHYL/BENZAMIDE | ELI LILLY AND COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0158526-A1 | Improvements in or relating to anticonvulsant agents | ELI LILLY AND COMPANY (US) | 1985-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137681-A1 | Sirtuin Inhibiting Compounds | SIRT2, SIRT1, SIRT3 | ALDH1A1 3168/4885KDM4E 1695/4885HPGD 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.