Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 7/20 | 0.36 |
| ▸ | PPARD | Q03181 | 7/20 | 0.36 |
| ▸ | PPARA | Q07869 | 7/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4293179 | 1.00 | KDM5A (0.36) | KDM5APHF8KDM4CEPHX2GPR84 | |
| Hydrochloric Acid SCHEMBL345724 | 1.00 | KDM5A (0.36) | KDM5APHF8KDM4CEPHX2GPR84 | |
| SCHEMBL4334125 | 0.99 | KDM5A (0.37) | KDM5APHF8KDM4CEPHX2GPR84 | |
| SCHEMBL4325880 | 0.99 | KDM5A (0.37) | KDM5APHF8KDM4CEPHX2GPR84 | |
| SCHEMBL21048580 | 0.99 | KDM5A (0.37) | KDM5APHF8KDM4CEPHX2GPR84 | |
| Hydrochloric Acid SCHEMBL9330621 | 0.97 | KDM5A (0.36) | KDM5APHF8KDM4CEPHX2GPR84 | |
| Hydrochloric Acid SCHEMBL4302158 | 0.93 | EPHX2 (0.47) | EPHX2PPARGPPARDPPARAPTPN1 | |
| Hydrochloric Acid SCHEMBL15948948 | 0.91 | EPHX2 (0.47) | EPHX2PPARGPPARDPPARAPTPN1 | |
| SCHEMBL4325883 | 0.89 | KDM5A (0.36) | KDM5APHF8KDM4CEPHX2GPR84 | |
| SCHEMBL4334127 | 0.89 | KDM5A (0.36) | KDM5APHF8KDM4CEPHX2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034019-B1 | COMPOSITION FOR NUCLEIC-ACID INTRODUCTION | HOKKAIDO SYSTEM SCIENCE CO LTD (JP) | 2014-08-20 | — | — | EP | disclosed |
| US-8227248-B2 | Composition for nucleic-acid transfection | HOKKAIDO SYSTEM SCIENCE CO., LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| US-20090239222-A1 | COMPOSITION FOR NUCLEIC-ACID TRANSFECTION | HOKKAIDO SYSTEM SCIENCE CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-2034019-A1 | COMPOSITION FOR NUCLEIC-ACID INTRODUCTION | Hokkaido System Science Co., Ltd. (JP) | 2009-03-11 | — | — | EP | disclosed |
| US-5874455-A | THIOL OR DISULFIDE DERIVATIVES FOR CATARACTS | GAKKO HOJIN KINKI DAIGAKU (JP) | 1999-02-23 | — | — | US | disclosed |
| US-5665770-A | PARTICLES CARRYING A DISULFIDE OR REDUCING THIOL | GAKKO HOJIN KINKI DAIGAKU (JP) | 1997-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239222-A1 | COMPOSITION FOR NUCLEIC-ACID TRANSFECTION | HNRNPH3, RNASEH1, NSUN3 | KDM5A 4776/4885PHF8 1556/4885KDM4C 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.