Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840547 | 0.87 | TSHR (0.39) | ALDH1A1TSHRL3MBTL1KMT2ACYP1A2 | |
| SCHEMBL7528740 | 0.85 | GAA (0.46) | ALDH1A1L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL9801002 | 0.83 | PTGS2 (0.46) | ALDH1A1KMT2AMEN1POLBMAPT | |
| SCHEMBL7536495 | 0.83 | PTGS2 (0.46) | ALDH1A1KMT2AMEN1POLBMAPT | |
| SCHEMBL1911387 | 0.82 | CYP1A2 (0.47) | ALDH1A1L3MBTL1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL7223406 | 0.82 | GABRA1 (0.46) | ALDH1A1TSHRL3MBTL1KMT2ACYP1A2 | |
| SCHEMBL7532751 | 0.82 | MAPK1 (0.47) | TSHRL3MBTL1KMT2ACYP1A2MEN1 | |
| SCHEMBL9511883 | 0.80 | POLB (0.56) | ALDH1A1L3MBTL1KMT2ACYP1A2MEN1 | |
| SCHEMBL3045742 | 0.80 | TSHR (0.56) | ALDH1A1TSHRL3MBTL1KMT2AMEN1 | |
| SCHEMBL7692381 | 0.79 | MEN1 (0.42) | ALDH1A1TSHRL3MBTL1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | claimed |
| US-5190946-A | Piperazine compounds restore sensitivity to drug resistant cancer cells | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | claimed |
| EP-0443569-A2 | Diamine derivatives and their use in oncology | F. HOFFMANN-LA ROCHE AG (CH) | 1991-08-28 | — | — | EP | claimed |
| EP-0358749-A1 | 1,4-SUBSTITUTED-2,3,5,6-TETRAHYDRO 1,3,6]TRIAZOCINO 1,2-a]BENZIMIDAZOLES AND INTERMEDIATES THEREFOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-03-21 | — | — | EP | claimed |
| US-4882323-A | ANTIARRYTHMIA AGENT INTERMEDIATES | AMERICAN HOME PRODUCTS (US) | 1989-11-21 | — | — | US | claimed |
| WO-1989008111-A1 | 1,4-SUBSTITUTED-2,3,5,6-TETRAHYDRO[1,3,6]TRIAZOCINO[1,2-a]BENZIMIDAZOLES AND INTERMEDIATES THEREFOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-09-08 | — | — | WO | claimed |
| US-4801706-A | ANTIARRHYTHMIA HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-31 | — | — | US | claimed |
| US-20250154353-A1 | RESIN COMPOSITION AND ARTICLE MADE THEREFROM | ELITE ELECTRONIC MATERIAL (KUNSHAN) CO., LTD. (CN) | 2025-05-15 | — | — | US | disclosed |
| WO-2021087113-A1 | LOCAL ANESTHETICS WITH SELECTIVE-SENSORY NERVE BLOCKADE | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2021-05-06 | — | — | WO | disclosed |
| US-10233157-B2 | SIK inhibitor for use in a method of treating an inflammatory and/or immune disorder | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| EP-3444031-A1 | HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) | 2019-02-20 | — | — | EP | disclosed |
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4801706-A | ANTIARRHYTHMIA HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0073326-B1 | PROCESS FOR PREPARING NITRILES FROM FORMAMIDES | BASF Aktiengesellschaft (DE) | 1985-10-23 | — | — | EP | disclosed |
| EP-0073326-A1 | Process for preparing nitriles from formamides | BASF Aktiengesellschaft (DE) | 1983-03-09 | — | — | EP | disclosed |
| US-4178387-A | ADMINISTERING AMIDINOUREAS | WILLIAM H. RORER, INC. (US) | 1979-12-11 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233157-B2 | SIK inhibitor for use in a method of treating an inflammatory and/or immune disorder | SIK1, SIK2, SGK1 | ALDH1A1 4501/4885TSHR 4596/4885L3MBTL1 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.