Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | FECH | P22830 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295871 | 0.99 | PTGS2 (0.37) | PTGS2LMNAMETNQO2FECH | |
| SCHEMBL2840173 | 0.83 | PLK1 (0.52) | PTGS2LMNAMETNQO2FECH | |
| SCHEMBL6248594 | 0.82 | APP (0.46) | PTGS2LMNAMETNQO2FECH | |
| SCHEMBL4295651 | 0.81 | PTGS2 (0.37) | PTGS2LMNAMETNQO2FECH | |
| SCHEMBL827525 | 0.78 | KMT2A (0.37) | PTGS2LMNAABCG2NPSR1MEN1 | |
| SCHEMBL6260996 | 0.78 | KMT2A (0.37) | PTGS2LMNAABCG2NPSR1MEN1 | |
| SCHEMBL499030 | 0.77 | ALOX5 (0.51) | NQO2CYP1A1CYP1B1ERN1KDM4E | |
| SCHEMBL1636058 | 0.76 | CYP1A1 (0.41) | PTGS2LMNANQO2CYP1A1CYP1B1 | |
| SCHEMBL1635863 | 0.74 | PTGS2 (0.37) | PTGS2LMNACYP1A1CYP1B1PTGS1 | |
| SCHEMBL1634113 | 0.73 | LMNA (0.44) | PTGS2LMNACYP1A1CYP1B1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306207-A1 | Treatment of Drug-Resistant Proliferative Disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-12-10 | — | — | US | disclosed |
| EP-1841420-A2 | TREATMENT OF DRUG-RESISTANT PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006074149-A2 | TREATMENT OF DRUG-RESISTANT PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306207-A1 | Treatment of Drug-Resistant Proliferative Disorders | ARSA, KSR1, RPS6KA1 | PTGS2 1148/4885LMNA 1217/4885MET 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.