SCHEMBL4293444

SCHEMBL4293444

CN1CCN(CCC(=O)Nc2ccc3c(c2)C(=O)c2cc(NC(=O)CCN4CCN(C)CC4)ccc2C3=O)CC1

nearest known ligand 0.95

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TERT O14746 13/20 0.95
MAPT P10636 2/20 0.79
ALDH1A1 P00352 2/20 0.79
LMNA P02545 1/20 0.67
TP53 P04637 2/20 0.64
L3MBTL1 Q9Y468 1/20 0.62
CA1 P00915 1/20 0.62
CA2 P00918 1/20 0.62
CA9 Q16790 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9629969 0.90 TERT (1.00) TERTMAPTALDH1A1TP53L3MBTL1
SCHEMBL4298492 0.89 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL8704683 0.89 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL8706042 0.88 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL4289287 0.88 TERT (0.74) TERTMAPTALDH1A1LMNA
SCHEMBL4300594 0.88 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL9630688 0.88 TERT (0.74) TERTMAPTALDH1A1LMNA
SCHEMBL3115635 0.88 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL8706439 0.88 TERT (1.00) TERTMAPTALDH1A1
SCHEMBL9630665 0.86 TERT (0.79) TERTMAPTALDH1A1LMNACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090253709-A1 SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES NATIONAL DEFENSE MEDICAL CENTER (TW) 2009-10-08 US disclosed
US-20090253709-A1 SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES NATIONAL DEFENSE MEDICAL CENTER (TW) 2009-10-08 US disclosed
US-20090253709-A1 SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES NATIONAL DEFENSE MEDICAL CENTER (TW) 2009-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253709-A1 SYNTHESIS, TELOMERASE INHIBITION AND CYTOTOXIC STUDIES ON 2,7-DISUBSTITUTED ANTHRAQUINONE DERIVATIVES TERT, NAT10, POT1 TERT 1/4885MAPT 4711/4885ALDH1A1 481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.