SCHEMBL9630665

SCHEMBL9630665

O=C(CCN1CCOCC1)Nc1ccc2c(c1)C(=O)c1ccc(NC(=O)CCN3CCOCC3)cc1C2=O

nearest known ligand 0.79

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TERT O14746 14/20 0.79
ALDH1A1 P00352 1/20 0.77
MAPT P10636 1/20 0.77
HPGD P15428 1/20 0.65
ALOX15 P16050 1/20 0.65
HTT P42858 1/20 0.65
ATM Q13315 1/20 0.64
LMNA P02545 1/20 0.64
CYP2C19 P33261 1/20 0.64
CA1 P00915 1/20 0.62
CA2 P00918 1/20 0.62
CA9 Q16790 1/20 0.62
TSHR P16473 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8704683 0.88 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL4298492 0.88 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL8706439 0.87 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL4300594 0.87 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL9630438 0.87 ALDH1A1 (0.64) TERTALDH1A1HPGDALOX15HTT
SCHEMBL8706042 0.87 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL3115635 0.87 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL4293444 0.86 TERT (0.95) TERTALDH1A1MAPTLMNACA1
SCHEMBL9629969 0.86 TERT (1.00) TERTALDH1A1MAPT
SCHEMBL4302435 0.85 TERT (0.79) TERTALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0482119-A1 INTERCALATING AGENTS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1992-04-29 EP claimed
WO-1991000265-A1 INTERCALATING AGENTS CANCER RESEARCH TECHNOLOGY LTD. (GB) 1991-01-10 WO claimed