Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315486 | 0.84 | NOTUM (0.59) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL17459260 | 0.81 | CYP1A2 (0.50) | CYP1A2NOTUMBRD9GAAAR | |
| SCHEMBL17459259 | 0.80 | CYP1A2 (0.53) | CYP1A2NOTUMBRD9GAAAR | |
| SCHEMBL17537376 | 0.79 | CYP1A2 (0.58) | CYP1A2NOTUMBRD9GAAAR | |
| SCHEMBL15766972 | 0.79 | NOTUM (0.54) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL4286769 | 0.79 | CYP1A2 (0.52) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL17931794 | 0.77 | CYP1A2 (0.57) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL17819292 | 0.77 | CYP1A2 (0.60) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL561046 | 0.76 | NOTUM (0.68) | CYP1A2NOTUMBRD9GSRPOLB | |
| SCHEMBL15837540 | 0.76 | BRD9 (0.54) | CYP1A2NOTUMBRD9POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120269872-A1 | NOVEL SALT 628 | ASTRAZENECA AB (SE) | 2012-10-25 | — | — | US | disclosed |
| US-20090105239-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269872-A1 | NOVEL SALT 628 | REN, SCN8A, SLC38A7 | CYP1A2 2967/4885NOTUM 1286/4885BRD9 179/4885 |
| US-20090105239-A1 | 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | SERPINB1, ELANE, MPO | CYP1A2 654/4885NOTUM 2654/4885BRD9 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.