Alpha-Tocopherol

Alpha-Tocopherol

SCHEMBL42939

Cc1c(C)c2c(c(C)c1O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2.O=C(O)CCC(=O)O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Alpha-Tocopherol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.86
TTPA P49638 3/20 0.86
MAPT P10636 2/20 0.86
MEN1 O00255 2/20 0.86
KMT2A Q03164 2/20 0.86
GSTP1 P09211 1/20 0.86
USP2 O75604 1/20 0.86
THRB P10828 1/20 0.86
CYP2C9 P11712 1/20 0.86
CYP2C19 P33261 1/20 0.86
ALOX5 P09917 3/20 0.78
NR1I2 O75469 2/20 0.78
GSTO1 P78417 2/20 0.76
PTPN1 P18031 1/20 0.76
PSEN1 P49768 2/20 0.71
PDE4A P27815 1/20 0.67
PDE3A Q14432 1/20 0.67
AKT1 P31749 2/20 0.51
PDPK1 O15530 1/20 0.51
PHLPP1 O60346 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Tocopherol SCHEMBL27995975 1.00 LMNA (0.86) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL28110607 0.98 LMNA (0.82) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL4556023 0.98 LMNA (0.82) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL27991376 0.97 LMNA (0.81) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL360251 0.97 LMNA (0.84) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL28434587 0.97 LMNA (0.84) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL3950296 0.97 LMNA (0.84) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL27697040 0.97 LMNA (0.84) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL358455 0.96 LMNA (0.82) LMNATTPAMAPTMEN1KMT2A
Alpha-Tocopherol SCHEMBL28838443 0.96 LMNA (0.82) LMNATTPAMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7484 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075463-A Pharmaceutical composition containing melagatran besylate and preparation method thereof 2026-05-26 CN claimed
US-20260124148-A1 POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY BHAMIS RES LABORATORY PVT LTD (IN) 2026-05-07 US claimed
US-12564552-B2 Oral product with a basic amine and an ion pairing agent Nicoventures Trading Limited (GB) 2026-03-03 US claimed
EP-4687502-A1 STARCHLESS MOLDING PROCESS FOR ORAL PRODUCTS Nicoventures Trading Limited (GB) 2026-02-11 EP claimed
EP-4687504-A1 ORAL COMPOSITIONS AND METHODS OF MANUFACTURE Nicoventures Trading Limited (GB) 2026-02-11 EP claimed
US-12533321-B2 Polypeptide formulations for oral delivery Bhami's Research Laboratory, Pvt. Ltd. (IN) 2026-01-27 US claimed
US-12527803-B2 Testosterone dodecanoate compositions and methods LIPOCINE, INC. 2026-01-20 US claimed
US-12453713-B2 Liquid formulation to treat a corneal tissue VISION ENGINEERING ITALY SRL (IT) 2025-10-28 US claimed
EP-4628583-A1 BICYCLIC ABASIC NUCLEIC ACID ANALOGS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM Shanghai Argo Biopharmaceutical Co., Ltd. (CN) 2025-10-08 EP claimed
US-20250268969-A1 OPHTHALMIC COMPOSITION Iromed Group S.r.l. (IT) 2025-08-28 US claimed
WO-1994020072-A1 SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF PHARMACIA AB (SE) 1994-09-15 WO claimed
WO-1993003720-A2 METHODS AND COMPOSITIONS FOR TREATING SUNBURNS TREVITHICK JOHN R (CA) 1993-03-04 WO claimed
US-5114957-A Tocopherol-based antiviral agents and method of using same BIODOR U.S. HOLDING (US) 1992-05-19 US claimed
US-4873088-A ADRIAMYCIN AND A SECONDARY COMPOUND TO ENHANCE ITS EFFECTIVENESS AND REDUCING TOXICITY; ENTRAPPED IN LIPOSOMES LIPOSOME TECHNOLOGY, INC. (US) 1989-10-10 US claimed
US-4870196-A MELTING WITH WAX, SPRAYING IN PRESENCE OF POWDER, FLUIDIZATION WITH AIR DANOCHEMO A/S (DK) 1989-09-26 US claimed
WO-1988000045-A1 METHOD OF PREPARING POWDERED, FREE-FLOWING TOCOPHERYL SUCCINATE DANOCHEMO A/S (DK) 1988-01-14 WO claimed
EP-0171009-A2 Purification of tocopherols by extraction HENKEL CORPORATION (a Delaware corp.) (US) 1986-02-12 EP claimed
EP-0153955-A1 LIPOSOME DELIVERY METHOD FOR DECREASING THE TOXICITY OF AN ANTITUMOR DRUG HEALTH RESEARCH, INC. (US) 1985-09-11 EP claimed
WO-1985000968-A1 LIPOSOME DELIVERY METHOD FOR DECREASING THE TOXICITY OF AN ANTITUMOR DRUG HEALTH RESEARCH, INC. (US) 1985-03-14 WO claimed
US-4269835-A Nasal composition for relieving nasal distress WHITTLE BARRY J 1981-05-26 US claimed