Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alpha-Tocopherol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.84 |
| ▸ | TTPA | P49638 | 3/20 | 0.84 |
| ▸ | MAPT | P10636 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.84 |
| ▸ | USP2 | O75604 | 1/20 | 0.84 |
| ▸ | THRB | P10828 | 1/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.76 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.72 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | AKT1 | P31749 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Tocopherol SCHEMBL28434587 | 1.00 | LMNA (0.84) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27697041 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL369660 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28838443 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL28479098 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL359306 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL358455 | 0.99 | LMNA (0.82) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL27697040 | 0.98 | LMNA (0.84) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL360251 | 0.98 | LMNA (0.84) | LMNATTPAMAPTMEN1KMT2A | |
| Alpha-Tocopherol SCHEMBL42939 | 0.97 | LMNA (0.86) | LMNATTPAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670838-B1 | AMPHIPHILIC BLOCK COPOLYMER AND POLYMERIC COMPOSITION COMPRISING THE SAME FOR DRUG DELIVERY | SAMYANG BIOPHARMACEUTICALS (KR) | 2015-12-09 | — | — | EP | disclosed |
| US-8349306-B2 | Hydrophilic comonomers of alkylene glycol, vinyl alcohols, vinylpyrrolidone, and/or acrylamide; hydrophobic comonoomer of lactic acid, glycolic acid, 6-hydroxycaproic acid, and/or dioxan-2-one substituted with tocopherol or cholesterol; stable micelles for delivery of anticarcinogenic agents | SAMYANG BIOPHARMACEUTICALS CORPORATION (KR) | 2013-01-08 | — | — | US | disclosed |
| EP-1670838-A4 | AMPHIPHILIC BLOCK COPOLYMER AND POLYMERIC COMPOSITION COMPRISING THE SAME FOR DRUG DELIVERY | SAMYANG CORP (KR) | 2009-07-08 | — | — | EP | disclosed |
| CN-100471886-C | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | SAMYANG CORP (KR) | 2009-03-25 | — | — | CN | disclosed |
| US-20080152616-A1 | Amphiphilic block copolymer and polymeric compostition comprising the same for drug delivery | SAMYANG HOLDINGS CORPORATION (KR) | 2008-06-26 | — | — | US | disclosed |
| US-7311901-B2 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | SAMYANG CORPORATION (KR) | 2007-12-25 | — | — | US | disclosed |
| EP-1670838-A1 | AMPHIPHILIC BLOCK COPOLYMER AND POLYMERIC COMPOSITION COMPRISING THE SAME FOR DRUG DELIVERY | Samyang Corporation (KR) | 2006-06-21 | — | — | EP | disclosed |
| CN-1780865-A | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | SAMYANG CORP (KR) | 2006-05-31 | — | — | CN | disclosed |
| US-20050201972-A1 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | SAMYANG CORPORATION | 2005-09-15 | — | — | US | disclosed |
| WO-2005035606-A1 | AMPHIPHILIC BLOCK COPOLYMER AND POLYMERIC COMPOSITION COMPRISING THE SAME FOR DRUG DELIVERY | SAMYANG CORPORATION (KR) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080152616-A1 | Amphiphilic block copolymer and polymeric compostition comprising the same for drug delivery | CETP, ABCB4, TPRKB | LMNA 872/4885TTPA 7/4885MAPT 1426/4885 |
| US-20050201972-A1 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | TTPA, CETP, CHKB | LMNA 322/4885TTPA 1/4885MAPT 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.