Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.64 |
| ▸ | CDK8 | P49336 | 8/20 | 0.61 |
| ▸ | AXL | P30530 | 2/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CCNC | P24863 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CCNH | P51946 | 1/20 | 0.52 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831501 | 0.84 | CDK8 (0.81) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL12127266 | 0.83 | RIPK1 (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL857125 | 0.83 | CDK8 (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL415099 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL29502620 | 0.81 | CDK8 (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL926536 | 0.81 | CDK8 (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| Hydrochloric Acid SCHEMBL28300266 | 0.79 | CDK8 (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL13576332 | 0.78 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL416750 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 | |
| SCHEMBL411814 | 0.77 | CDK8 (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306126-A1 | Indole Derivatives | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| CN-101448827-A | Indole derivatives | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306126-A1 | Indole Derivatives | MTOR, IDO1, AKT1S1 | PIK3CA 27/4885PIK3CD 17/4885PIK3CB 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.