Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200201 | 0.86 | RAB9A (0.45) | MEN1KMT2ARAB9ACCNE1CDK2 | |
| SCHEMBL31125168 | 0.84 | F2 (0.46) | MEN1KMT2ACCNE1CDK2CDK5 | |
| SCHEMBL31125084 | 0.81 | CHEK1 (0.59) | CCNE1CDK2CDK5ALDH1A1MAPT | |
| SCHEMBL2589885 | 0.81 | CHEK1 (0.59) | CCNE1CDK2CDK5ALDH1A1MAPT | |
| SCHEMBL3715011 | 0.79 | MEN1 (0.58) | MEN1KMT2AIDO1TMPRSS4RAB9A | |
| SCHEMBL1967584 | 0.78 | HCAR3 (0.63) | MEN1KMT2ATMPRSS4RAB9ADEGS1 | |
| SCHEMBL16172589 | 0.78 | MAPT (0.57) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL20644592 | 0.78 | CCNE1 (0.46) | MEN1KMT2ARAB9ACCNE1CDK2 | |
| SCHEMBL14355062 | 0.78 | CCNE1 (0.46) | MEN1KMT2ARAB9ACCNE1CDK2 | |
| SCHEMBL13977907 | 0.78 | CCNE1 (0.46) | MEN1KMT2ARAB9ACCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270416-A1 | N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER | SENTINEL ONCOLOGY LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20090270416-A1 | N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER | SENTINEL ONCOLOGY LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20090270416-A1 | N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER | SENTINEL ONCOLOGY LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20050176733-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| WO-2005072733-A1 | DYARYLUREA COMPOUNDS AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270416-A1 | N-OXIDES OF DIARYLUREA DERIVATIVES AND THEIR USE AS Chk1 INHIBITORS FOR THE TREATMENT OF CANCER | CHEK1, CHEK2, CDK1 | MEN1 2156/4885KMT2A 888/4885IDO1 1829/4885 |
| US-20050176733-A1 | Chk-1 inhibitors | CHEK1, CHEK2, CHKA | MEN1 2119/4885KMT2A 1260/4885IDO1 4062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.