SCHEMBL4294778

SCHEMBL4294778

Nc1nc(=O)[nH]c(O)c1O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
CHEK1 O14757 1/20 0.33
AURKA O14965 1/20 0.33
DAPK3 O43293 1/20 0.33
JAK2 O60674 1/20 0.33
ABL1 P00519 1/20 0.33
NTRK1 P04629 1/20 0.33
CSF1R P07333 1/20 0.33
RET P07949 1/20 0.33
IGF1R P08069 1/20 0.33
PDGFRB P09619 1/20 0.33
PIM1 P11309 1/20 0.33
FGFR1 P11362 1/20 0.33
PRKACA P17612 1/20 0.33
KDR P35968 1/20 0.33
MAP2K2 P36507 1/20 0.33
FLT3 P36888 1/20 0.33
MAPK8 P45983 1/20 0.33
CSNK1A1 P48729 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7587289 0.70 CHEK1 (0.39) TSHRL3MBTL1CHEK1AURKADAPK3
Hydrochloric Acid SCHEMBL8723152 0.68 CHEK1 (0.38) TSHRL3MBTL1CHEK1AURKADAPK3
Sulfuric Acid SCHEMBL9007348 0.67 CHEK1 (0.34) TSHRL3MBTL1CHEK1AURKADAPK3
Sulfurous Acid SCHEMBL7661068 0.67 CHEK1 (0.34) TSHRL3MBTL1CHEK1AURKADAPK3
SCHEMBL3167526 0.67 CDK1 (0.33) L3MBTL1
SCHEMBL6730539 0.67 TYMP (0.43) TSHRL3MBTL1CHEK1AURKADAPK3
SCHEMBL3180710 0.67 CDK1 (0.52) TSHRDYRK1ALMNA
SCHEMBL3167024 0.64 ALDH1A1 (0.50) L3MBTL1
SCHEMBL1095503 0.63
SCHEMBL19628746 0.62 KDM4E (0.39) TSHRL3MBTL1PDE3BPDE3ACTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
US-20090149411-A1 IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF DYNAVAX TECHNOLOGIES CORPORATION 2009-06-11 US claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO disclosed
US-20180334730-A1 METHODS AND KITS FOR DETERMINING DNA REPAIR CAPACITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2018-11-22 US disclosed
US-9938587-B2 Methods and kits for determining DNA repair capacity MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2018-04-10 US disclosed
US-20170218416-A1 COMPOSITIONS AND METHODS FOR SINGLE-MOLECULE CONSTRUCTION OF DNA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-03 US disclosed
EP-3143140-A1 COMPOSITIONS AND METHODS FOR SINGLE-MOLECULE CONSTRUCTION OF DNA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-03-22 EP disclosed
WO-2015176070-A1 COMPOSITIONS AND METHODS FOR SINGLE-MOLECULE CONSTRUCTION OF DNA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-11-19 WO disclosed
US-20140227701-A1 METHODS AND KITS FOR DETERMINING DNA REPAIR CAPACITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2014-08-14 US disclosed
WO-2013043936-A1 METHODS AND KITS FOR DETERMINING DNA REPAIR CAPACITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-03-28 WO disclosed
US-20120244525-A1 Oligonucleotide Adapters: Compositions and Methods of Use NEW ENGLAND BIOLABS, INC. (US) 2012-09-27 US disclosed