SCHEMBL7587289

SCHEMBL7587289

Nc1nc(=O)[nH]c(N)c1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.39
AURKA O14965 1/20 0.39
DAPK3 O43293 1/20 0.39
JAK2 O60674 1/20 0.39
ABL1 P00519 1/20 0.39
NTRK1 P04629 1/20 0.39
CSF1R P07333 1/20 0.39
RET P07949 1/20 0.39
IGF1R P08069 1/20 0.39
PDGFRB P09619 1/20 0.39
PIM1 P11309 1/20 0.39
FGFR1 P11362 1/20 0.39
PRKACA P17612 1/20 0.39
KDR P35968 1/20 0.39
MAP2K2 P36507 1/20 0.39
FLT3 P36888 1/20 0.39
MAPK8 P45983 1/20 0.39
CSNK1A1 P48729 1/20 0.39
CDK8 P49336 1/20 0.39
GSK3A P49840 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8723152 0.97 CHEK1 (0.38) CHEK1AURKADAPK3JAK2ABL1
Sulfurous Acid SCHEMBL7661068 0.89 CHEK1 (0.34) CHEK1AURKADAPK3JAK2ABL1
Sulfuric Acid SCHEMBL9007348 0.89 CHEK1 (0.34) CHEK1AURKADAPK3JAK2ABL1
SCHEMBL6730539 0.75 TYMP (0.43) CHEK1AURKADAPK3JAK2ABL1
SCHEMBL4294778 0.70 TSHR (0.35) CHEK1AURKADAPK3JAK2ABL1
SCHEMBL6842093 0.66 NPSR1 (0.47) CHEK1AURKADAPK3JAK2ABL1
SCHEMBL19628746 0.65 KDM4E (0.39) L3MBTL1ALDH1A1MAPTTSHRCTSK
SCHEMBL1271646 0.63 CDK1 (0.56) DYRK1AL3MBTL1ALDH1A1MEN1MAPT
SCHEMBL460884 0.63 PNP (0.39) DYRK1AL3MBTL1ALDH1A1MAPTCDK1
SCHEMBL524230 0.62 MAPT (0.53) CHEK1AURKADAPK3JAK2ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120037794-A Preparation method and application of solvent-resistant polyamide composite membrane 南京工业大学 2025-05-27 CN claimed
EP-1026166-B1 Process for the preparation of folic acid BASF AG (DE) 2002-10-02 EP claimed
US-6348593-B1 REACTING 2,2,3,3-TETRAALKOXYPROPANOL/1-/ WITH TRIAMINOPYRIMIIDONE AND P-AMINOBENZOYL-L-GLUTAMIC ACID; CYCLIZATION BASF AKTIENGESELLSCHAFT (DE) 2002-02-19 US claimed
EP-1026166-A1 Process for the preparation of folic acid BASF AKTIENGESELLSCHAFT (DE) 2000-08-09 EP claimed
EP-0608693-B1 Process for the preparation of folic acid HOFFMANN LA ROCHE (CH) 1996-10-23 EP claimed
US-5410056-A Method for the production of folic acid HOFFMAN-LA ROCHE INC. (US) 1995-04-25 US claimed
EP-0608693-A2 Process for the preparation of folic acid F. HOFFMANN-LA ROCHE AG (CH) 1994-08-03 EP claimed
JP-7316159-A None JP disclosed
CN-120037794-A Preparation method and application of solvent-resistant polyamide composite membrane 南京工业大学 2025-05-27 CN disclosed
US-11339295-B2 Oxidative dye couplers with novel auxochrome substituents and azomethine dyes and leuco forms thereof WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2022-05-24 US disclosed
WO-2019032671-A1 OXIDATIVE DYE COUPLERS WITH NOVEL AUXOCHROME SUBSTITUENTS AND AZOMETHINE DYES AND LEUCO FORMS THEREOF COTY INC. (US) 2019-02-14 WO disclosed
EP-1026166-B1 Process for the preparation of folic acid BASF AG (DE) 2002-10-02 EP disclosed
US-6348593-B1 REACTING 2,2,3,3-TETRAALKOXYPROPANOL/1-/ WITH TRIAMINOPYRIMIIDONE AND P-AMINOBENZOYL-L-GLUTAMIC ACID; CYCLIZATION BASF AKTIENGESELLSCHAFT (DE) 2002-02-19 US disclosed
JP-H07316159-A PRODUCTION OF FOLIC ACID F HOFFMANN LA ROCHE AG 1995-12-05 JP disclosed
US-5410056-A Method for the production of folic acid HOFFMAN-LA ROCHE INC. (US) 1995-04-25 US disclosed
US-5410056-A Method for the production of folic acid HOFFMAN-LA ROCHE INC. (US) 1995-04-25 US disclosed
EP-0608693-A2 Process for the preparation of folic acid F. HOFFMANN-LA ROCHE AG (CH) 1994-08-03 EP disclosed
EP-0608693-A2 Process for the preparation of folic acid F. HOFFMANN-LA ROCHE AG (CH) 1994-08-03 EP disclosed
US-4043750-A OXIDATION HENKEL & CIE GMBH (DT) 1977-08-23 US disclosed
US-4043750-A OXIDATION HENKEL & CIE GMBH (DT) 1977-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11339295-B2 Oxidative dye couplers with novel auxochrome substituents and azomethine dyes and leuco forms thereof CRY1, PPOX, DAO CHEK1 2211/4885AURKA 1994/4885DAPK3 2814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.