Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 known ✓ | P04629 | 1/20 | 0.34 |
| ▸ | MAP2K2 known ✓ | P36507 | 1/20 | 0.34 |
| ▸ | MAP2K1 known ✓ | Q02750 | 1/20 | 0.34 |
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 known ✓ | Q16620 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8723152 | 0.87 | CHEK1 (0.38) | CHEK1AURKADAPK3JAK2ABL1 | |
| Sulfurous Acid SCHEMBL7661068 | 0.83 | CHEK1 (0.34) | CHEK1AURKADAPK3JAK2ABL1 | |
| Sulfuric Acid SCHEMBL6482329 | 0.78 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| Sulfuric Acid SCHEMBL21495047 | 0.71 | CDK1 (0.47) | DYRK1ATSHRCDK2MEN1ALDH1A1 | |
| Sulfuric Acid SCHEMBL4612293 | 0.67 | PDPK1 (0.34) | TSHRCDK2MAPT | |
| Sulfuric Acid SCHEMBL20815930 | 0.67 | PDPK1 (0.34) | TSHRCDK2MAPT | |
| Sulfuric Acid SCHEMBL121743 | 0.67 | PDPK1 (0.34) | TSHRCDK2MAPT | |
| SCHEMBL6730539 | 0.67 | TYMP (0.43) | CHEK1AURKADAPK3JAK2ABL1 | |
| SCHEMBL4294778 | 0.67 | TSHR (0.35) | CHEK1AURKADAPK3JAK2ABL1 | |
| Sulfuric Acid SCHEMBL9621165 | 0.66 | PDPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608693-B1 | Process for the preparation of folic acid | HOFFMANN LA ROCHE (CH) | 1996-10-23 | — | — | EP | disclosed |
| US-5410056-A | Method for the production of folic acid | HOFFMAN-LA ROCHE INC. (US) | 1995-04-25 | — | — | US | disclosed |
| EP-0608693-A2 | Process for the preparation of folic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1994-08-03 | — | — | EP | disclosed |