Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28343733 | 0.98 | KDM4E (0.51) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL2731197 | 0.84 | CTNNB1 (0.51) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL28350848 | 0.82 | KDM4E (0.44) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL4294800 | 0.82 | SLC6A3 (0.39) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL8628415 | 0.82 | SGMS2 (0.56) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL8647971 | 0.78 | KDM4E (0.50) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL7111180 | 0.77 | KDM4E (0.55) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL2493557 | 0.77 | KDM4E (0.55) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL30255502 | 0.76 | KDM4E (0.53) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL1982429 | 0.76 | KDM4E (0.53) | KDM4EHSD17B10HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115806907-A | Streptomyces abyssochliae, preparation method and application of anti-feeding and antifungal active substance thereof | 中国科学院沈阳应用生态研究所 | 2023-03-17 | — | — | CN | disclosed |
| CN-111233821-B | Novel antimycin derivative containing 3-hydroxybenzene acid group and preparation method and application thereof | 上海交通大学医学院附属仁济医院 | 2022-12-27 | — | — | CN | disclosed |
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHISON CANCER RESEARCH CENTER (US) | 2009-08-13 | — | — | US | disclosed |
| US-7241804-B1 | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2007-07-10 | — | — | US | disclosed |
| US-20050239873-A1 | 2 Methoxy antimycin a derivatives and methods of use | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2005-10-27 | — | — | US | disclosed |
| EP-1218368-A4 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | HUTCHINSON FRED CANCER RES (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1218368-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | Fred Hutchinson Cancer Research Center (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001014365-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | BCL2, BAX, BCL2A1 | KDM4E 4139/4885HSD17B10 2863/4885HPGD 2910/4885 |
| US-20050239873-A1 | 2 Methoxy antimycin a derivatives and methods of use | BCL2, BCL2L2, BCL2L1 | KDM4E 3892/4885HSD17B10 908/4885HPGD 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.