Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801771 | 0.85 | CYP3A4 (0.42) | L3MBTL1KDM4EHSD17B10LMNAHPGD | |
| SCHEMBL4294796 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10CYP1A2CYP2C9LMNA | |
| SCHEMBL2731197 | 0.81 | CTNNB1 (0.51) | SLC6A3KDM4EHSD17B10LMNAHPGD | |
| Ammonia Solution, Strong SCHEMBL28343733 | 0.81 | KDM4E (0.51) | KDM4EHSD17B10CYP1A2CYP2C9LMNA | |
| SCHEMBL28350848 | 0.79 | KDM4E (0.44) | SLC6A3KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL27568172 | 0.79 | LMNA (0.58) | KDM4EHSD17B10LMNAHPGDMAPT | |
| SCHEMBL28179037 | 0.79 | ALDH1A1 (0.52) | KDM4EHSD17B10CYP2C9HPGDKMT2A | |
| SCHEMBL28636158 | 0.77 | KMT2A (0.51) | L3MBTL1KDM4ELMNAHPGDMAPT | |
| SCHEMBL28033367 | 0.76 | NR4A1 (0.52) | L3MBTL1KDM4EHPGDMAPTKMT2A | |
| SCHEMBL8628415 | 0.76 | SGMS2 (0.56) | KDM4EHSD17B10CYP2C9LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHISON CANCER RESEARCH CENTER (US) | 2009-08-13 | — | — | US | disclosed |
| US-7241804-B1 | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2007-07-10 | — | — | US | disclosed |
| US-20050239873-A1 | 2 Methoxy antimycin a derivatives and methods of use | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2005-10-27 | — | — | US | disclosed |
| EP-1218368-A4 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | HUTCHINSON FRED CANCER RES (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1218368-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | Fred Hutchinson Cancer Research Center (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001014365-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | BCL2, BAX, BCL2A1 | SLC6A3 4630/4885L3MBTL1 902/4885KDM4E 4139/4885 |
| US-20050239873-A1 | 2 Methoxy antimycin a derivatives and methods of use | BCL2, BCL2L2, BCL2L1 | SLC6A3 3966/4885L3MBTL1 295/4885KDM4E 3892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.