SCHEMBL4295987

SCHEMBL4295987

C=CCNc1[c]ccc(N2CCCCC2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.48
MEN1 O00255 5/20 0.48
KMT2A Q03164 5/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
KDM4E B2RXH2 3/20 0.40
GLA P06280 1/20 0.40
TSHR P16473 1/20 0.40
NPY1R P25929 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PRMT6 Q96LA8 1/20 0.35
POLB P06746 2/20 0.35
GBA1 P04062 1/20 0.35
ALDH1A1 P00352 6/20 0.33
LMNA P02545 4/20 0.33
HTT P42858 3/20 0.33
S100B P04271 2/20 0.33
TERT O14746 2/20 0.33
GAA P10253 1/20 0.33
PKM P14618 1/20 0.33
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4301248 0.86 MAPT (0.38) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL4052124 0.73 TRIM24 (0.40) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL4599615 0.70 LMNA (0.36) MEN1KMT2AL3MBTL1HSD17B10ALDH1A1
SCHEMBL4600271 0.70 LMNA (0.42) MEN1KMT2AL3MBTL1KDM4EALDH1A1
SCHEMBL4598425 0.70 HPGD (0.37) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL1900057 0.68 ALDH1A1 (0.43) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL3143049 0.68 ALDH1A1 (0.43) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL2094918 0.68 ALDH1A1 (0.43) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL5744022 0.66 ALDH1A1 (0.42) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL21681522 0.66 ALDH1A1 (0.42) MAPTMEN1KMT2AL3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same YUYU PHARMA, INC. (KR) 2009-07-02 US claimed
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same YUYU PHARMA, INC. (KR) 2009-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170847-A1 Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same GSK3B, GSK3A, MAP3K3 MAPT 119/4885MEN1 3177/4885KMT2A 1812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.