Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MGMT | P16455 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299839 | 0.88 | GRM5 (1.00) | GRM5CYP11B1CYP11B2RECQLMRGPRX4 | |
| SCHEMBL8773165 | 0.83 | GRM5 (0.78) | GRM5CYP11B1CYP11B2MRGPRX4GABRG2 | |
| SCHEMBL31060977 | 0.82 | GRM5 (1.00) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL4292772 | 0.82 | GRM5 (1.00) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL8963208 | 0.81 | GRM5 (0.74) | GRM5CYP11B1CYP11B2MRGPRX4GABRG2 | |
| SCHEMBL8546238 | 0.78 | GRM5 (0.64) | GRM5CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL23286912 | 0.73 | GRM5 (0.57) | GRM5FFAR1 | |
| SCHEMBL29738117 | 0.73 | GRM5 (0.57) | GRM5FFAR1 | |
| SCHEMBL29413268 | 0.71 | — | — | |
| SCHEMBL7016006 | 0.71 | GRM5 (0.53) | GRM5CYP11B1CYP11B2RECQLLOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130149721-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-06-13 | — | — | US | disclosed |
| US-20090239888-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |