Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 1.00 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060977 | 1.00 | GRM5 (1.00) | GRM5MRGPRX4MAOBDHFRHTR2A | |
| SCHEMBL8773165 | 0.87 | GRM5 (0.78) | GRM5MRGPRX4MAOBCYP11B1CYP11B2 | |
| SCHEMBL4299874 | 0.87 | GRM5 (1.00) | GRM5MRGPRX4MAOBDHFRKDM4E | |
| SCHEMBL8963208 | 0.85 | GRM5 (0.74) | GRM5MRGPRX4MAOBCYP11B1CYP11B2 | |
| SCHEMBL4297770 | 0.82 | GRM5 (1.00) | GRM5MRGPRX4CYP11B1CYP11B2 | |
| SCHEMBL4299839 | 0.79 | GRM5 (1.00) | GRM5MRGPRX4CYP11B1CYP11B2 | |
| SCHEMBL8546238 | 0.77 | GRM5 (0.64) | GRM5CYP11B1CYP11B2 | |
| SCHEMBL7292908 | 0.77 | MAOB (0.67) | GRM5MRGPRX4MAOBDHFR | |
| SCHEMBL6285396 | 0.75 | GRM5 (0.60) | GRM5MRGPRX4MAOBHTR2AHTR2C | |
| SCHEMBL6287266 | 0.74 | HTR2A (0.60) | GRM5MAOBDHFRHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130149721-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-06-13 | — | — | US | disclosed |
| US-20090239888-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |