Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297770 | 0.88 | GRM5 (1.00) | GRM5POLBCYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL8773165 | 0.80 | GRM5 (0.78) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL23504272 | 0.79 | GRM5 (0.65) | GRM5JAK2JAK1CDK2TYK2 | |
| SCHEMBL31060977 | 0.79 | GRM5 (1.00) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL4292772 | 0.79 | GRM5 (1.00) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL8963208 | 0.77 | GRM5 (0.74) | GRM5CYP11B1CYP11B2MRGPRX4 | |
| SCHEMBL8546238 | 0.75 | GRM5 (0.64) | GRM5CYP11B1CYP11B2 | |
| SCHEMBL4299874 | 0.74 | GRM5 (1.00) | GRM5MRGPRX4MAPT | |
| SCHEMBL29738117 | 0.70 | GRM5 (0.57) | GRM5 | |
| SCHEMBL23286912 | 0.70 | GRM5 (0.57) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130149721-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-06-13 | — | — | US | disclosed |
| US-20090239888-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |