Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014810 | 0.85 | CFTR (0.44) | HSD11B1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL1013178 | 0.83 | MEN1 (0.40) | HSD11B1MEN1APEX1KMT2A | |
| SCHEMBL1013177 | 0.83 | MEN1 (0.40) | HSD11B1MEN1APEX1KMT2A | |
| SCHEMBL1014376 | 0.83 | MEN1 (0.40) | HSD11B1MEN1APEX1KMT2A | |
| SCHEMBL1015020 | 0.78 | HSD11B1 (0.52) | HSD11B1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL1015670 | 0.77 | HSD11B1 (0.50) | HSD11B1KMT2AHPGDSMN1; SMN2TMEM97 | |
| SCHEMBL1015366 | 0.77 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1015365 | 0.77 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1015671 | 0.77 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28059199 | 0.77 | HSD11B1 (0.51) | HSD11B1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | CYP2S1, HSD11B1, HSD3B1 | HSD11B1 2/4885MEN1 1994/4885APEX1 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.