Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | ACHE | P22303 | 2/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.65 |
| ▸ | TNF | P01375 | 3/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7793146 | 0.93 | PDE4A (0.81) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL8362364 | 0.91 | RXFP1 (0.67) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10784646 | 0.90 | PDE4A (0.84) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7802154 | 0.89 | PDE4A (0.75) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10346579 | 0.88 | PDE4A (0.76) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7793096 | 0.88 | PDE4A (0.84) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10873386 | 0.88 | PDE4A (0.77) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7564102 | 0.87 | PDE4A (0.60) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7802893 | 0.87 | PDE4A (0.83) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10871504 | 0.87 | PDE4A (0.74) | PDE4ALMNACYP1A2NFKB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636507-A | Host defense mechanism enhancement | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-01-13 | — | — | US | claimed |
| JP-54112893-A | — | — | None | — | — | JP | disclosed |
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-20 | — | — | US | disclosed |
| WO-2006036928-A2 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | WAYNE STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| JP-S54112893-A | PREPARATION OF 1-(5'-OXOHEXYL)-3,7-DIETHYLXANTHINE | KOHJIN CO LTD | 1979-09-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | MMP9, MMP10, MMP17 | PDE4A 1051/4885LMNA 1476/4885CYP1A2 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.