Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 8/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299306 | 1.00 | TRPA1 (0.55) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL4299298 | 1.00 | TRPA1 (0.55) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL3673077 | 0.81 | CYP11B2 (0.53) | TRPA1MAPTALDH1A1MAPK1KMT2A | |
| SCHEMBL3673074 | 0.81 | CYP11B2 (0.53) | TRPA1MAPTALDH1A1MAPK1KMT2A | |
| SCHEMBL3667051 | 0.81 | TRPA1 (0.66) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL3667053 | 0.81 | TRPA1 (0.66) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL3667048 | 0.81 | TRPA1 (0.66) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL4297061 | 0.81 | TRPA1 (0.66) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL3667187 | 0.80 | TRPA1 (0.60) | TRPA1SIGMAR1ABCB11GABRA1MAPT | |
| SCHEMBL3667185 | 0.80 | TRPA1 (0.60) | TRPA1SIGMAR1ABCB11GABRA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751850-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2017-09-05 | — | — | US | claimed |
| US-20150065538-A1 | TRPA1 ANTAGONISTS | ABBVIE INC (US) | 2015-03-05 | — | — | US | claimed |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-10-22 | — | — | US | claimed |
| US-9751850-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20150065538-A1 | TRPA1 ANTAGONISTS | ABBVIE INC (US) | 2015-03-05 | — | — | US | disclosed |
| US-8877784-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065538-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885SIGMAR1 266/4885ABCB11 700/4885 |
| US-20090264480-A1 | TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885SIGMAR1 266/4885ABCB11 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.