Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332150 | 0.91 | PDE7A (0.33) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4766490 | 0.80 | MAPK14 (0.44) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4068948 | 0.79 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5254602 | 0.79 | MAPK14 (0.34) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL3228361 | 0.78 | DYRK3 (0.36) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL4289881 | 0.78 | MAPK11 (0.34) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5738188 | 0.78 | MAPK13 (0.41) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5738681 | 0.75 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5256394 | 0.73 | PRKD3 (0.39) | MAPK13MAPK12MAPK11MAPK14KCNH2 | |
| SCHEMBL5256916 | 0.71 | MAPK14 (0.37) | MAPK13MAPK12MAPK11MAPK14KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2031965-A2 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007147104-A2 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |