Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056370 | 0.82 | MAPK11 (0.34) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3226831 | 0.81 | PDE7A (0.34) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5332150 | 0.80 | PDE7A (0.33) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4766490 | 0.79 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4299724 | 0.79 | MAPK13 (0.33) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5738188 | 0.78 | MAPK13 (0.41) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL3226827 | 0.78 | PDE7A (0.39) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4068948 | 0.78 | MAPK13 (0.39) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5256394 | 0.75 | PRKD3 (0.39) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5738681 | 0.75 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865959-A2 | PROCESS FOR PREPARING PYRIDOÝ2,3-D¨PYRIMIDIN-7-ONE AND 3,4-DIHYDROPYRIMIDOÝ4,5-D¨PYRIMIDIN-2(1H)-ONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006104917-A2 | PROCESS FOR PREPARING PYRIDO[2,3-D]PYRIMIDIN-7-ONE AND 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-10-05 | — | — | WO | disclosed |