Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060977 | 0.87 | GRM5 (1.00) | GRM5KDM4EHPGDMRGPRX4MAOB | |
| SCHEMBL4292772 | 0.87 | GRM5 (1.00) | GRM5KDM4EHPGDMRGPRX4MAOB | |
| SCHEMBL19755770 | 0.78 | GRM5 (0.63) | GRM5MAOBMAPT | |
| SCHEMBL7292908 | 0.75 | MAOB (0.67) | GRM5MRGPRX4MAOBDHFRMAOA | |
| SCHEMBL4299839 | 0.74 | GRM5 (1.00) | GRM5MRGPRX4MAPT | |
| SCHEMBL8773165 | 0.74 | GRM5 (0.78) | GRM5MRGPRX4MAOB | |
| SCHEMBL8963208 | 0.72 | GRM5 (0.74) | GRM5MRGPRX4MAOB | |
| SCHEMBL28937457 | 0.72 | GRM5 (0.56) | GRM5MRGPRX4MAOBMAOA | |
| SCHEMBL29559472 | 0.72 | GRM5 (0.56) | GRM5MRGPRX4MAOBMAOA | |
| SCHEMBL21241049 | 0.70 | GRM5 (0.53) | GRM5KDM4EHPGDMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130149721-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-06-13 | — | — | US | disclosed |
| US-20090239888-A1 | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | US | disclosed |