Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PRNP | P04156 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827081 | 0.86 | CYP1A2 (0.52) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| Bromide SCHEMBL29161153 | 0.84 | CYP1A2 (0.50) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL31373891 | 0.75 | CYP1A2 (0.45) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL1261380 | 0.74 | CYP1A2 (0.48) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL10543603 | 0.73 | CYP1A2 (0.47) | ALDH1A1CYP1A2HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL9540374 | 0.73 | ALDH1A1 (0.38) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL404595 | 0.73 | NCF1 (0.42) | ALDH1A1CYP1A2HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL4741484 | 0.73 | CYP1A2 (0.47) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL12915337 | 0.71 | CYP1A2 (0.48) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP | |
| SCHEMBL20559366 | 0.71 | NCF1 (0.48) | ALDH1A1CYP1A2HSD17B10KDM4EPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |