Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26512422 | 0.80 | NCF1 (0.42) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL9009627 | 0.76 | NCF1 (0.50) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL3267344 | 0.73 | NCF1 (0.43) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL1261380 | 0.73 | CYP1A2 (0.48) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL2557489 | 0.73 | NCF1 (0.43) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL4300128 | 0.73 | ALDH1A1 (0.40) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL30106721 | 0.72 | NCF1 (0.46) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL827081 | 0.72 | CYP1A2 (0.52) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL10020390 | 0.72 | ALDH1A1 (0.53) | NCF1CYP1A2NOS2BACE1CA12 | |
| SCHEMBL27568530 | 0.72 | NCF1 (0.52) | NCF1CYP1A2NOS2BACE1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324173-B2 | Peptides useful as dual caspase-2/-6 inhibitors and their biological applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-12-04 | — | — | US | disclosed |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CHAUVIER DAVID (FR) | 2012-01-26 | — | — | US | disclosed |
| WO-2009083930-A1 | CASPASE-8 INHIBITORS AND USES THEREOF | THERAPTOSIS (FR) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083929-A1 | CASPASE-1 INHIBITORS AND USES THEREOF | THERAPTOSIS (FR) | 2009-07-09 | — | — | WO | disclosed |
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-12 | — | — | US | disclosed |
| EP-1817328-A2 | NEW PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | Theraptosis S.A. (FR) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056487-A2 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | THERAPTOSIS S.A. (FR) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CASP6, CASP2, CASP4 | NCF1 3006/4885CYP1A2 2148/4885NOS2 333/4885 |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CASP6, CASP2, CASP1 | NCF1 1135/4885CYP1A2 4555/4885NOS2 1973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.