SCHEMBL4300941

SCHEMBL4300941

CCCC(C)CCC(N)C(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BHMT Q93088 2/20 0.63
BHMT2 Q9H2M3 1/20 0.63
SLC1A2 P43004 5/20 0.53
SLC1A1 P43005 5/20 0.53
SLC1A3 P43003 4/20 0.53
GRIK1 P39086 4/20 0.53
GRIK2 Q13002 4/20 0.53
ACE2 Q9BYF1 1/20 0.47
GSR P00390 2/20 0.46
SLC7A5 Q01650 1/20 0.46
GRM8 O00222 1/20 0.46
GRM6 O15303 1/20 0.46
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
CYP1A2 P05177 1/20 0.46
GRM5 P41594 1/20 0.46
GRIA1 P42261 1/20 0.46
GRIA2 P42262 1/20 0.46
GRIA3 P42263 1/20 0.46
GRIA4 P48058 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1199871 1.00 BHMT (0.63) BHMTBHMT2SLC1A2SLC1A1SLC1A3
SCHEMBL20232925 0.88 GSR (0.55) BHMTBHMT2SLC1A2SLC1A1SLC1A3
SCHEMBL4312680 0.88 BHMT (0.59) BHMTBHMT2SLC1A2SLC1A1SLC1A3
SCHEMBL21036202 0.86 ACE2 (0.67) BHMTBHMT2SLC1A2SLC1A1SLC1A3
SCHEMBL5034721 0.84 BHMT (0.60) BHMTBHMT2SLC1A2SLC1A1SLC1A3
SCHEMBL1199780 0.84 BHMT (0.60) BHMTBHMT2SLC1A2SLC1A1SLC1A3
Norvaline SCHEMBL38404 0.84
Norvaline SCHEMBL197812 0.84
Norvaline SCHEMBL21114359 0.84 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GRIK1GRIK2
Norvaline SCHEMBL840389 0.84 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GRIK1GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020219867-A1 PYRIDONE AMIDE CO-CRYSTAL COMPOSITIONS FOR THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2020-10-29 WO disclosed
EP-2922849-B1 POLYMORPHS OF 4-{[4-({[4-(2,2,2-TRIFLUOROETHOXY)-1,2-BENZISOXAZOL-3-YL]OXY}METHYL)PIPERIDIN-1-YL]METHYL}-TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID AS 5-HYDROXYTRYPTAMINE-4 (5-HT4) RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES RAQUALIA PHARMA INC (JP) 2017-07-12 EP disclosed
EP-2024272-A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME Renovis, Inc. (US) 2009-02-18 EP disclosed
WO-2007133637-A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME RENOVIS, INC. (US) 2007-11-22 WO disclosed
EP-1853269-A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME Renovis, Inc. (US) 2007-11-14 EP disclosed
WO-2006093832-A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME RENOVIS, INC. (US) 2006-09-08 WO disclosed
EP-1667722-A1 COMBINATIONS OF ALPHA-2-DELTA LIGANDS AND ACETYLCHOLINESTERASE INHIBITORS Pfizer Limited (GB) 2006-06-14 EP disclosed
WO-2005027975-A1 COMBINATIONS OF ALPHA-2-DELTA LIGANDS AND ACETYLCHOLINESTERASE INHIBITORS PFIZER LIMITED (GB) 2005-03-31 WO disclosed