Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 2/20 | 0.63 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.63 |
| ▸ | SLC1A2 | P43004 | 5/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300941 | 1.00 | BHMT (0.63) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL20232925 | 0.88 | GSR (0.55) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL4312680 | 0.88 | BHMT (0.59) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL21036202 | 0.86 | ACE2 (0.67) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL5034721 | 0.84 | BHMT (0.60) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL1199780 | 0.84 | BHMT (0.60) | BHMTBHMT2SLC1A2SLC1A1SLC1A3 | |
| Norvaline SCHEMBL38404 | 0.84 | — | — | |
| Norvaline SCHEMBL197812 | 0.84 | — | — | |
| Norvaline SCHEMBL21114359 | 0.84 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Norvaline SCHEMBL840389 | 0.84 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140206670-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | PFIZER INC. (US) | 2014-07-24 | — | — | US | disclosed |
| US-20120329781-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | PFIZER INC | 2012-12-27 | — | — | US | disclosed |
| US-20110039899-A1 | Gabapentin for the Treatment of Overactive Bladder, Stress Incontinence and BPH | PFIZER INC | 2011-02-17 | — | — | US | disclosed |
| US-20100081718-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | PFIZER INC | 2010-04-01 | — | — | US | disclosed |
| US-7517909-B2 | Amino acids with affinity for the α2δ-protein | PFIZER INC (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090036487-A1 | Combinations | PFIZER INC. | 2009-02-05 | — | — | US | disclosed |
| US-20060247282-A1 | Methods for using amino acids with affinity for the alpha2delta-protein | BRAMSON CANDACE | 2006-11-02 | — | — | US | disclosed |
| US-7112610-B2 | Methods for using amino acids with affinity for the α2δ-protein | WARNER-LAMBERT COMPANY LLC (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060154972-A1 | Amino acids with affinity for the alpha-2-delta-protein | BARTA NANCY S | 2006-07-13 | — | — | US | disclosed |
| US-7064147-B2 | Amino acids with affinity for the α-2-delta-protein | WARNER-LAMBERT COMPANY (US) | 2006-06-20 | — | — | US | disclosed |
| US-20050124669-A1 | Methods for using amino acids with affinity for the alpha2delta-protein | BRAMSON CANDACE (US) | 2005-06-09 | — | — | US | disclosed |
| US-20040180958-A1 | Method of treatment | PFIZER PRODUCTS INC. | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039899-A1 | Gabapentin for the Treatment of Overactive Bladder, Stress Incontinence and BPH | GABRB2, GABRB3, GABRB1 | BHMT 322/4885BHMT2 469/4885SLC1A2 239/4885 |
| US-20090036487-A1 | Combinations | CHRNE, CHRND, CHRNG | BHMT 709/4885BHMT2 996/4885SLC1A2 423/4885 |
| US-20040180958-A1 | Method of treatment | BPHL, ADRA2B, ADRB2 | BHMT 333/4885BHMT2 599/4885SLC1A2 2587/4885 |
| US-20050124669-A1 | Methods for using amino acids with affinity for the alpha2delta-protein | SCN2A, OPRD1, SCN1A | BHMT 3740/4885BHMT2 3646/4885SLC1A2 29/4885 |
| US-20060154972-A1 | Amino acids with affinity for the alpha-2-delta-protein | SCN2A, OPRD1, SCN1A | BHMT 3435/4885BHMT2 3537/4885SLC1A2 31/4885 |
| US-20120329781-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | SLC6A2, OPRD1, ADRB2 | BHMT 2493/4885BHMT2 2777/4885SLC1A2 78/4885 |
| US-20140206670-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | SLC6A2, OPRD1, ADRB2 | BHMT 2493/4885BHMT2 2777/4885SLC1A2 78/4885 |
| US-20060247282-A1 | Methods for using amino acids with affinity for the alpha2delta-protein | SCN2A, OPRD1, SCN1A | BHMT 3740/4885BHMT2 3646/4885SLC1A2 29/4885 |
| US-20100081718-A1 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS | SLC6A2, SIGMAR1, OPRL1 | BHMT 2732/4885BHMT2 2715/4885SLC1A2 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.