Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5530603 | 0.88 | HTT (0.49) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4794804 | 0.84 | MAPT (0.47) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL5317250 | 0.84 | ACHE (0.50) | MAPTGAAKDM4EALDH1A1MAPK1 | |
| SCHEMBL1437039 | 0.81 | MET (0.45) | KITMEN1KMT2AKDR | |
| SCHEMBL1437032 | 0.78 | MAPT (0.42) | MAPTGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL4309489 | 0.78 | HTT (0.49) | MAPTKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL9933482 | 0.76 | PDE5A (0.38) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL4796659 | 0.76 | KDM4E (0.49) | MAPTGAAKDM4EALDH1A1TSHR | |
| SCHEMBL513403 | 0.75 | KIT (0.45) | MAPTGAAKDM4EALDH1A1KDM4C | |
| SCHEMBL1457569 | 0.74 | MEN1 (0.47) | MAPTGAAKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157482-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC | 2012-06-21 | — | — | US | disclosed |
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | CORIUM INTERNATIONAL, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| EP-1838700-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | Novartis AG (CH) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006072589-A2 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131437-A1 | DISUBSTITUTED UREAS AS KINASE INHIBITORS | UCK2, ULK2, MAP3K1 | MAPT 527/4885GAA 1410/4885KDM4E 834/4885 |
| US-20120157482-A1 | COMPOUNDS AND METHODS | NQO1, CYP1B1, CYP1A1 | MAPT 3800/4885GAA 1295/4885KDM4E 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.