Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | AOC2 | O75106 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695491 | 1.00 | HDAC3 (0.49) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL30887999 | 1.00 | HDAC3 (0.49) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL4934593 | 1.00 | HDAC3 (0.49) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL27274507 | 0.92 | HDAC3 (0.45) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL5847076 | 0.90 | HPGD (0.47) | HDAC3HDAC1HDAC2CA2HPGD | |
| SCHEMBL30525289 | 0.87 | HDAC3 (0.47) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| Benzenesulfonamide SCHEMBL4672289 | 0.87 | CA2 (0.47) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL229558 | 0.86 | HPGD (0.49) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL1567147 | 0.86 | HDAC3 (0.46) | HDAC3HDAC1HDAC2CA2HSD11B1 | |
| SCHEMBL2286036 | 0.86 | HPGD (0.49) | HDAC3HDAC1HDAC2CA2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 138 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153595-A1 | CHROMANE DERIVATIVES AS EGFR SELECTIVE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-25 | — | — | WO | claimed |
| US-9743665-B2 | Fungicidal 3-{phenyl[heterocyclylmethoxy)imino]methyl}-oxadiazolone derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-08-29 | — | — | US | claimed |
| EP-1673362-A2 | METHOD FOR PRODUCING CHROMANE DERIVATIVES THAT ARE DEVOID OF ENANTIOMERS AND ARE SUBSTITUTED IN POSITION 2 | MERCK PATENT GmbH (DE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005037817-A2 | METHOD FOR PRODUCING CHROMANE DERIVATIVES THAT ARE DEVOID OF ENANTIOMERS AND ARE SUBSTITUTED IN POSITION 2 | MERCK PATENT GMBH (DE) | 2005-04-28 | — | — | WO | claimed |
| EP-0231139-B1 | DIHYDROBENZOFURANE AND CHROMANE CARBOXAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS NEUROLEPTICS | Laboratoires DELAGRANGE (FR) | 1991-12-04 | — | — | EP | claimed |
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | claimed |
| CN-87100978-A | Dihydrobenzofuran-and chroman-carboxamide derivatives, processes for their preparation and their use as neuroleptics | — | 1987-09-16 | — | — | CN | claimed |
| EP-0115142-B1 | CHROMAN COMPOUNDS | ICI AMERICAS INC. (US) | 1986-11-05 | — | — | EP | claimed |
| EP-0115142-A1 | Chroman compounds | ICI AMERICAS INC. (US) | 1984-08-08 | — | — | EP | claimed |
| US-20250145594-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2025-05-08 | — | — | US | disclosed |
| WO-2024153595-A1 | CHROMANE DERIVATIVES AS EGFR SELECTIVE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-25 | — | — | WO | disclosed |
| EP-3505513-B1 | ISOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATEMTN OF OPHTHALMIC DISORDERS | IND TECH RES INST (TW) | 2023-09-27 | — | — | EP | disclosed |
| EP-4237413-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| EP-3676297-B1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC (US) | 2023-05-17 | — | — | EP | disclosed |
| CN-1039809-A | The aminomethyl tetraline that replaces and the preparation of heterocycle homologue thereof | BAYER AG (DE) | 1990-02-21 | — | — | CN | disclosed |
| CN-87100978-A | Dihydrobenzofuran-and chroman-carboxamide derivatives, processes for their preparation and their use as neuroleptics | — | 1987-09-16 | — | — | CN | disclosed |
| EP-0231139-A2 | Dihydrobenzofurane and chromane carboxamide derivatives, processes for their preparation and their use as neuroleptics | Laboratoires DELAGRANGE (FR) | 1987-08-05 | — | — | EP | disclosed |
| EP-0231139-A2 | Dihydrobenzofurane and chromane carboxamide derivatives, processes for their preparation and their use as neuroleptics | Laboratoires DELAGRANGE (FR) | 1987-08-05 | — | — | EP | disclosed |
| EP-0115142-B1 | CHROMAN COMPOUNDS | ICI AMERICAS INC. (US) | 1986-11-05 | — | — | EP | disclosed |
| EP-0115142-A1 | Chroman compounds | ICI AMERICAS INC. (US) | 1984-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250145594-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | HDAC3 359/4885HDAC1 309/4885HDAC2 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.