Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305886 | 0.91 | KMT2A (0.34) | KDM4EALDH1A1BRD4POLBCPB2 | |
| Butane SCHEMBL6297560 | 0.72 | KDM4E (0.42) | KDM4EBRD4TDP1SCN9A | |
| SCHEMBL3352920 | 0.70 | KDM4E (0.44) | KDM4EBRD4TDP1 | |
| SCHEMBL4302702 | 0.70 | KDM4E (0.39) | KDM4EALDH1A1TDP1HTTPOLB | |
| SCHEMBL4791398 | 0.68 | POLB (0.35) | KDM4EBRD4TDP1POLB | |
| SCHEMBL28503732 | 0.67 | NFKB1 (0.31) | KDM4EALDH1A1CPB2 | |
| SCHEMBL15273698 | 0.67 | HTR2C (0.37) | KDM4EALDH1A1BRD4TDP1POLB | |
| SCHEMBL4305882 | 0.66 | TLR7 (0.38) | KDM4EALDH1A1TDP1HTTPOLB | |
| SCHEMBL202924 | 0.66 | KDM4E (0.39) | KDM4EALDH1A1BRD4TDP1HTT | |
| SCHEMBL14604067 | 0.66 | KDM4E (0.39) | KDM4EALDH1A1TDP1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270443-A1 | 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. | 2009-10-29 | — | — | US | disclosed |
| WO-2006026760-A2 | 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270443-A1 | 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS | IL2, IL4I1, IFNG | KDM4E 3088/4885ALDH1A1 821/4885BRD4 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.