Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 4/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.43 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.43 |
| ▸ | CACNA2D4 | Q7Z3S7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4311903 | 0.88 | AVPR1B (0.48) | AVPR1BSTSCHEK2GPR119TNKS | |
| SCHEMBL4310057 | 0.88 | AVPR1B (0.49) | AVPR1BSTSCHEK2GPR119TP53 | |
| SCHEMBL4303339 | 0.77 | AVPR1B (0.79) | AVPR1B | |
| SCHEMBL3171016 | 0.77 | STS (0.57) | STSCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL29731062 | 0.77 | STS (0.57) | STSCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3962648 | 0.77 | STS (0.48) | STSGPR119TP53POLB | |
| SCHEMBL4310061 | 0.77 | AVPR1B (0.54) | AVPR1B | |
| SCHEMBL4311907 | 0.76 | AVPR1B (0.52) | AVPR1B | |
| SCHEMBL8018250 | 0.74 | TNKS (0.46) | TNKSPARP1TNKS2 | |
| SCHEMBL2793124 | 0.71 | GPR119 (0.65) | STSCACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |