Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 3/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310057 | 0.93 | AVPR1B (0.49) | AVPR1BCHEK2STSGPR119TP53 | |
| SCHEMBL4302952 | 0.88 | AVPR1B (0.46) | AVPR1BCHEK2STSGPR119TP53 | |
| SCHEMBL4310061 | 0.82 | AVPR1B (0.54) | AVPR1B | |
| SCHEMBL2351366 | 0.78 | GPR119 (0.54) | CHEK2STSGPR119SLC2A1TP53 | |
| SCHEMBL3962648 | 0.75 | STS (0.48) | STSGPR119TP53POLBSMN1; SMN2 | |
| SCHEMBL26668458 | 0.74 | SLC2A1 (0.59) | CHEK2GPR119SLC2A1CSF1R | |
| SCHEMBL31071546 | 0.74 | STS (0.53) | CHEK2STSGPR119SLC2A1TP53 | |
| SCHEMBL3256200 | 0.73 | GPR119 (0.57) | CHEK2STSGPR119 | |
| SCHEMBL8018250 | 0.73 | TNKS (0.46) | TNKSPARP1TNKS2CSF1R | |
| SCHEMBL13097087 | 0.71 | SLC2A1 (0.57) | CHEK2GPR119SLC2A1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |