Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.57 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL43029 | 1.00 | PTGS1 (0.57) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Arginine SCHEMBL6676451 | 0.87 | PTGS2 (0.41) | PTGS2NPY4RNPY1RNPY2RNPY5R | |
| Ibuprofen SCHEMBL7038934 | 0.86 | EPHX1 (0.46) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Hydrochloric Acid SCHEMBL7161657 | 0.81 | THRB (0.65) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL44616 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| (R)-Ibuprophen SCHEMBL8579043 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL8733957 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Ibuprofen SCHEMBL44617 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| Dexibuprofen SCHEMBL875767 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA | |
| (R)-Ibuprophen SCHEMBL29696062 | 0.81 | THRB (0.73) | PTGS1PTGS2CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12514833-B2 | Combination of ibuprofen and tramadol for relieving pain | FARMALÍDER, S.A. (ES) | 2026-01-06 | — | — | US | claimed |
| US-20250177307-A1 | IMPROVED MANUFACTURING PROCESS | HALEON (SUZHOU) PHARMACEUTICAL CO., LTD. (CN) | 2025-06-05 | — | — | US | claimed |
| CN-118662429-A | Ibuprofen eutectic rectal gel and preparation method thereof | 南京海融医药科技股份有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-117442735-A | Pharmaceutical composition, preparation method and application thereof | 武汉九珑人福药业有限责任公司 | 2024-01-26 | — | — | CN | claimed |
| CN-114080221-B | Combination of ibuprofen and tramadol for pain relief | 法玛利德尔公司 | 2023-12-05 | — | — | CN | claimed |
| CN-114886874-B | Oral instant film and preparation method thereof | 沈阳信达泰康医药科技有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-116490167-A | Improved manufacturing process | 惠氏制药有限公司 | 2023-07-25 | — | — | CN | claimed |
| EP-3996699-B1 | COMBINATION OF IBUPROFEN AND TRAMADOL FOR RELIEVING PAIN | FARMALIDER SA (ES) | 2023-06-28 | — | — | EP | claimed |
| WO-2023021433-A1 | IMPROVED MANUFACTURING PROCESS | Wyeth Pharmaceutical Co., Ltd. (CN) | 2023-02-23 | — | — | WO | claimed |
| EP-4137122-A1 | IMPROVED MANUFACTURING PROCESS | Wyeth Pharmaceutical Co., Ltd. (CN) | 2023-02-22 | — | — | EP | claimed |
| CN-1268327-C | Brufen arginine pseudoephedrine hydrochloride compound formulation | HANGZHOU RONGLI MEDICINE TECHN (CN) | 2006-08-09 | — | — | CN | claimed |
| CN-1246306-C | New method for preparing brufen arginine salt | UNIV CHINA PHARMA (CN) | 2006-03-22 | — | — | CN | claimed |
| EP-1249234-B1 | Method of preventing retinopathy of prematurity in a neonate | FARMACON IL LLC (US) | 2006-02-22 | — | — | EP | claimed |
| CN-1237964-C | Method for preparing composition granules containing ibuprofen amino guanidyl valeric acid | RONGLI MEDICINE SCI & TECH CO (CN) | 2006-01-25 | — | — | CN | claimed |
| CN-1562966-A | New method for preparing brufen arginine salt | UNIV CHINA PHARMACY (CN) | 2005-01-12 | — | — | CN | claimed |
| CN-1559409-A | Compound prepn. contg. Brufen arginine codeine | 杭州容立医药科技有限公司 | 2005-01-05 | — | — | CN | claimed |
| CN-1557293-A | Brufen arginine pseudoephedrine hydrochloride compound formulation | 杭州容立医药科技有限公司 | 2004-12-29 | — | — | CN | claimed |
| CN-1528278-A | Method for preparing composition granules containing ibuprofen amino guanidyl valeric acid | 杭州容立医药科技有限公司 | 2004-09-15 | — | — | CN | claimed |
| EP-1249234-A1 | Method of preventing retinopathy of prematurity in a neonate | Farmacon-IL, LLC (US) | 2002-10-16 | — | — | EP | claimed |
| US-6344479-B1 | AMINO ACID SALT OF IBUPROFEN | FARMACON-IL, LLC | 2002-02-05 | — | — | US | claimed |