Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | NPY4R | P50391 | 3/20 | 0.40 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL8585894 | 0.88 | MAPT (0.58) | PTGS2KMT2A | |
| Ibuprofen SCHEMBL43030 | 0.87 | PTGS1 (0.57) | PTGS2NPY4RNPY1RNPY2RNPY5R | |
| Ibuprofen SCHEMBL43029 | 0.87 | PTGS1 (0.57) | PTGS2NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL17164662 | 0.86 | LMNA (0.47) | OTCGRM2GRM3C3AR1POLB | |
| Arginine SCHEMBL17164663 | 0.86 | LMNA (0.47) | OTCGRM2GRM3C3AR1POLB | |
| Arginine SCHEMBL16879777 | 0.85 | KIF11 (0.47) | OTCNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28268971 | 0.85 | OTC (0.53) | OTCNOS3NOS1NOS2KMT2A | |
| Arginine SCHEMBL26914670 | 0.84 | KIF11 (0.46) | OTCNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL7107267 | 0.84 | LTA4H (0.41) | OTCNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL1287134 | 0.83 | OTC (0.43) | OTCNOS3NOS1NOS2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436268-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033481-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-04-24 | — | — | WO | disclosed |