Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304235 | 0.88 | MAPT (0.37) | LMNAMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL4301399 | 0.88 | CYP1A2 (0.34) | LMNAALDH1A1KDM4E | |
| SCHEMBL4311072 | 0.86 | MRGPRX4 (0.37) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4302813 | 0.84 | ALDH1A1 (0.35) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4304477 | 0.83 | TP53BP1 (0.38) | MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL4302849 | 0.82 | MCL1 (0.35) | LMNAALDH1A1KDM4E | |
| SCHEMBL4305020 | 0.77 | LMNA (0.46) | LMNAMAPTMEN1CASP3KMT2A | |
| SCHEMBL4302638 | 0.76 | RXFP1 (0.37) | LMNAMAPTMEN1KMT2AHTR1A | |
| SCHEMBL4311981 | 0.75 | LMNA (0.44) | LMNAMAPTMEN1CASP3KMT2A | |
| SCHEMBL13125216 | 0.72 | MAPT (0.44) | MAPTMEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |