Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 2/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28833440 | 0.85 | ALDH1A1 (0.57) | TSHRSMN1; SMN2CASP1ALDH1A1TP53 | |
| SCHEMBL78586 | 0.82 | SMN1; SMN2 (0.59) | TSHRSMN1; SMN2CASP1ALDH1A1TP53 | |
| SCHEMBL12165951 | 0.79 | ABL1 (0.58) | SMN1; SMN2CASP1ALDH1A1CA1CA2 | |
| SCHEMBL605638 | 0.78 | KDM4E (0.47) | TSHRALDH1A1TP53CA1CA2 | |
| SCHEMBL8815443 | 0.78 | KEAP1 (0.50) | ALDH1A1CA1CA2GAAKDM4E | |
| SCHEMBL7567906 | 0.78 | CA12 (0.55) | TSHRALDH1A1CA1CA2GAA | |
| SCHEMBL29598455 | 0.78 | KDM4E (0.47) | TSHRALDH1A1TP53CA1CA2 | |
| SCHEMBL7069948 | 0.78 | TSHR (0.53) | TSHRSMN1; SMN2CASP1ALDH1A1TP53 | |
| SCHEMBL7069945 | 0.78 | TSHR (0.53) | TSHRSMN1; SMN2CASP1ALDH1A1TP53 | |
| Lithium SCHEMBL31456603 | 0.77 | KDM4E (0.46) | TSHRALDH1A1TP53CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856414-B2 | Compositions, systems and methods of making coated additive components | DOBER CHEMICAL CORP. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20140364345-A1 | Compositions, Systems and Methods of Making Coated Additive Components | DOBER CHEMICAL CORP. | 2014-12-11 | — | — | US | disclosed |
| US-20130255951-A1 | Compositions, Systems and Methods for Releasing Additive Components | DOBER CHEMICAL CORPORATION (US) | 2013-10-03 | — | — | US | disclosed |
| US-8338455-B2 | Pyridines or pyrimidines having 4-(hydrogenated 1-pyridyl- or hydrogenated 1-isoquinolyl rings, e.g., N-(4-chlorophenyl)-2-(pyridin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide; kinase inhibitors; inflammation, angiogenesis and cancer | AMGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338455-B2 | Pyridines or pyrimidines having 4-(hydrogenated 1-pyridyl- or hydrogenated 1-isoquinolyl rings, e.g., N-(4-chlorophenyl)-2-(pyridin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide; kinase inhibitors; inflammation, angiogenesis and cancer | AMGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338455-B2 | Pyridines or pyrimidines having 4-(hydrogenated 1-pyridyl- or hydrogenated 1-isoquinolyl rings, e.g., N-(4-chlorophenyl)-2-(pyridin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide; kinase inhibitors; inflammation, angiogenesis and cancer | AMGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2118088-B1 | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer | AMGEN INC (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2118088-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN TREATING INFLAMMATION, ANGIOGENESIS AND CANCER | Amgen Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| US-7524434-B2 | Controlled release cooling additive composition | DOBER CHEMICAL CORPORATION (US) | 2009-04-28 | — | — | US | disclosed |
| WO-2008079292-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN TREATING INFLAMMATION, ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| US-4060677-A | Process for molecular weight lowering of vinyl halide polymers employing saturated carbon to carbon bonded aldehydes | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |
| US-4046658-A | Process for electrocoating aminimide containing compositions | GENERAL MOTORS CORPORATION (US) | 1977-09-06 | — | — | US | disclosed |
| US-4029621-A | COATINGS | PPG INDUSTRIES, INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-4028329-A | Process for the bulk polymerization of vinyl halide polymers showing reduced reactor scale formation | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4012460-A | Method of polymerizing vinyl chloride with olefin-acrylic ester copolymers and composition thereof | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-03-15 | — | — | US | disclosed |
| US-4007235-A | Method of preparing vinyl halide polymers and copolymers with polyolefins | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-02-08 | — | — | US | disclosed |
| US-4003962-A | Method of preparing an easy processing polyvinyl halide by an in-process reaction | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1977-01-18 | — | — | US | disclosed |
| US-3970612-A | BULK POLYMERIZATION | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1976-07-20 | — | — | US | disclosed |
| US-3959106-A | EPOXY COMPOUNDS; SULFIDES | PPG INDUSTRIES, INC. (US) | 1976-05-25 | — | — | US | disclosed |
| US-3956422-A | MOLDING MATERIALS | HOOKER CHEMICALS & PLASTICS CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |