Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080771 | 1.00 | TOP2A (0.36) | TOP2ADNMT1ADRB1 | |
| SCHEMBL887464 | 1.00 | TOP2A (0.36) | TOP2ADNMT1ADRB1 | |
| SCHEMBL430399 | 1.00 | TOP2A (0.36) | TOP2ADNMT1ADRB1 | |
| SCHEMBL24090515 | 0.90 | TOP2A (0.41) | TOP2A | |
| SCHEMBL22043415 | 0.88 | TOP2A (0.38) | TOP2ADNMT1ADRB1 | |
| SCHEMBL13314174 | 0.88 | TOP2A (0.38) | TOP2ADNMT1ADRB1 | |
| SCHEMBL1566766 | 0.88 | TOP2A (0.38) | TOP2ADNMT1ADRB1 | |
| SCHEMBL29720461 | 0.86 | TOP2A (0.36) | TOP2ADNMT1ADRB1 | |
| SCHEMBL2611636 | 0.86 | ALB (0.34) | DNMT1ADRB1 | |
| SCHEMBL29720353 | 0.85 | TOP2A (0.35) | TOP2ADNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-02-24 | — | — | US | disclosed |
| US-20240318245-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-09-26 | — | — | US | disclosed |
| US-11939631-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-03-26 | — | — | US | disclosed |
| US-20210381043-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-09 | — | — | US | disclosed |
| EP-3795577-A1 | MODIFIED NUCLEOTIDES | Illumina Cambridge Limited (GB) | 2021-03-24 | — | — | EP | disclosed |
| US-20200399692-A1 | MODIFIED NUCLEOTIDES | SOLEXA LIMITED (GB) | 2020-12-24 | — | — | US | disclosed |
| US-20200208211-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-07-02 | — | — | US | disclosed |
| US-20190136308-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-05-09 | — | — | US | disclosed |
| EP-3363809-A1 | MODIFIED NUCLEOTIDES FOR POLYNUCLEOTIDE SEQUENCING | Illumina Cambridge Limited (GB) | 2018-08-22 | — | — | EP | disclosed |
| US-10000801-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-19 | — | — | US | disclosed |
| US-8071739-B2 | Modified nucleotides | ILLUMINA CAMBRIDGE LIMITED (GB) | 2011-12-06 | — | — | US | disclosed |
| US-7982029-B2 | Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-07-19 | — | — | US | disclosed |
| US-7883869-B2 | for sequencing single-stranded DNA by employing a nanopore and modified nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100292452-A1 | Modified nucleotides | ILLUMINA CAMBRIDGE LTD | 2010-11-18 | — | — | US | disclosed |
| US-7771973-B2 | sequencing reactions where nucleotide or nucleoside molecules modified by reversible covalent attachment of 3'-OH blocking groups thereto, are used where blocked nucleotide or nucleoside molecules are required | ILLUMINA CAMBRIDGE LIMITED (GB) | 2010-08-10 | — | — | US | disclosed |
| US-20100092952-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-15 | — | — | US | disclosed |
| US-20100041029-A1 | SYNTHESIS OF FOUR COLOR 3'O-ALLYL, MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-02-18 | — | — | US | disclosed |
| US-20090325172-A1 | Modified nucleotides | SOLEXA LIMITED | 2009-12-31 | — | — | US | disclosed |
| US-7541444-B2 | Modified nucleotides | ILLUMINA CAMBRIDGE LIMITED (GB) | 2009-06-02 | — | — | US | disclosed |
| US-20070166705-A1 | Modified nucleotides | ILLUMINA CAMBRIDGE LIMITED (GB) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292452-A1 | Modified nucleotides | ADAR, NT5C2, NSUN2 | TOP2A 1418/4885DNMT1 241/4885ADRB1 2083/4885 |
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | POLN, DNMT3A, POLRMT | TOP2A 28/4885DNMT1 7/4885ADRB1 3270/4885 |
| US-20200399692-A1 | MODIFIED NUCLEOTIDES | ADAR, NT5C2, NSUN2 | TOP2A 1418/4885DNMT1 241/4885ADRB1 2083/4885 |
| US-20070166705-A1 | Modified nucleotides | NT5C2, ADAR, DUT | TOP2A 1364/4885DNMT1 246/4885ADRB1 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.