Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL9359044 | 0.94 | ALDH1A1 (0.44) | ALDH1A1KDM4ECHRM2CHRM1KMT2A | |
| SCHEMBL323447 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL22996224 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL22996249 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL22996243 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL626439 | 0.86 | ALDH1A1 (0.41) | ALDH1A1KDM4ECHRM2CHRM1KMT2A | |
| SCHEMBL16227396 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KDM4ECHRM2CHRM1KMT2A | |
| SCHEMBL2882040 | 0.83 | MEN1 (0.43) | ALDH1A1KDM4ECHRM2CHRM1KMT2A | |
| Alcohol SCHEMBL7566185 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ECHRM2CHRM1KMT2A | |
| SCHEMBL28919252 | 0.81 | HSD11B1 (0.41) | ALDH1A1KDM4ECHRM2CHRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635236-B2 | In situ remediation of inorganic contaminants using stabilized zero-valent iron nanoparticles | AUBURN UNIVERSITY (US) | 2009-12-22 | — | — | US | disclosed |
| US-20070256985-A1 | In Situ Remediation of Inorganic Contaminants Using Stabilized Zero-Valent Iron Nanoparticles | AUBURN UNIVERSITY | 2007-11-08 | — | — | US | disclosed |