Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.59 |
| ▸ | CTSS | P25774 | 3/20 | 0.57 |
| ▸ | CTSK | P43235 | 2/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347053 | 1.00 | KLK5 (0.59) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL4304250 | 1.00 | KLK5 (0.59) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL4304252 | 1.00 | KLK5 (0.59) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL15950936 | 0.93 | CTSS (0.53) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL18560546 | 0.93 | CTSS (0.53) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL21473748 | 0.88 | KLK5 (0.72) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL84524 | 0.88 | KLK5 (0.72) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL6292728 | 0.88 | KLK5 (0.72) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL1196457 | 0.88 | KLK5 (0.72) | KLK5CTSSCTSKCTSLCTSB | |
| SCHEMBL24687315 | 0.86 | PPARA (0.64) | KLK5CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009038412-A2 | BETA-SECRETASE INHIBITING COMPOUNDS | LG LIFE SCIENCES, LTD. (KR) | 2009-03-26 | — | — | WO | disclosed |