Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309925 | 0.98 | KMT2A (0.41) | KMT2AELANELMNATP53SMN1; SMN2 | |
| SCHEMBL4308201 | 0.96 | KMT2A (0.41) | KMT2AELANELMNATP53SMN1; SMN2 | |
| SCHEMBL4302638 | 0.87 | RXFP1 (0.37) | KMT2ALMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL4306446 | 0.86 | CNR2 (0.39) | KMT2ALMNATP53SMN1; SMN2MEN1 | |
| SCHEMBL4308163 | 0.82 | KCNN4 (0.33) | KMT2ASMN1; SMN2MEN1HPGDALDH1A1 | |
| SCHEMBL4304177 | 0.77 | THRB (0.34) | KMT2ASMN1; SMN2MEN1ALDH1A1L3MBTL1 | |
| SCHEMBL17410073 | 0.75 | ERCC5 (0.42) | KMT2ASMN1; SMN2MEN1HPGDALDH1A1 | |
| SCHEMBL26924584 | 0.75 | ALDH1A1 (0.41) | LMNASMN1; SMN2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL17410087 | 0.74 | ERCC5 (0.43) | KMT2ASMN1; SMN2MEN1HPGDALDH1A1 | |
| SCHEMBL4304235 | 0.73 | MAPT (0.37) | KMT2ALMNATP53SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |