Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309925 | 0.88 | KMT2A (0.41) | XPO1ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4304978 | 0.86 | KMT2A (0.41) | XPO1ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4304177 | 0.86 | THRB (0.34) | ATMKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL4308163 | 0.86 | KCNN4 (0.33) | KDM4ENPC1RAB9AALDH1A1NPSR1 | |
| SCHEMBL4302638 | 0.84 | RXFP1 (0.37) | KDM4ENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4308201 | 0.83 | KMT2A (0.41) | XPO1ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL4304184 | 0.82 | HRH3 (0.46) | LMNANPSR1HPGDKMT2APOLB | |
| SCHEMBL4304477 | 0.76 | TP53BP1 (0.38) | ATMKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL26924584 | 0.73 | ALDH1A1 (0.41) | KDM4ENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4306225 | 0.72 | AVPR1B (0.49) | KDM4EALDH1A1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |