Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CD69 | Q07108 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308611 | 0.83 | PTGDR2 (0.42) | KDM4EPTGDR2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6629949 | 0.80 | KDM4E (0.51) | ALDH1A1KDM4EGAAPTGDR2MEN1 | |
| SCHEMBL15889293 | 0.76 | TLR8 (0.46) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL9161697 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAAPOLBMAPT | |
| SCHEMBL13912950 | 0.71 | KDM4E (0.38) | ALDH1A1KDM4EPTGDR2MEN1KMT2A | |
| SCHEMBL4308934 | 0.70 | HPGDS (0.44) | ALDH1A1KDM4EGAASMN1; SMN2POLB | |
| SCHEMBL13912924 | 0.69 | SMN1; SMN2 (0.38) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL5000594 | 0.69 | NPSR1 (0.67) | ALDH1A1KDM4EGAAPTGDR2SMN1; SMN2 | |
| SCHEMBL14273081 | 0.69 | PTPN7 (0.63) | KDM4EMEN1KMT2APTPN7SMN1; SMN2 | |
| SCHEMBL152565 | 0.69 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062280-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062280-A1 | Ophthalmic Compositions for Treating Ocular Hypertension | KCNN3, KCNN1, KCNN2 | ALDH1A1 1707/4885KDM4E 1800/4885GAA 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.