Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.36 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.36 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.36 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306263 | 0.88 | CACNB4 (0.46) | AVPR1BGPR119CACNB4CACNA1ACACNA1G | |
| SCHEMBL4305704 | 0.83 | AVPR1B (0.66) | AVPR1B | |
| SCHEMBL4305698 | 0.74 | AVPR1B (0.66) | AVPR1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL4306414 | 0.73 | AVPR1B (0.47) | AVPR1BTNKSPARP1TNKS2GRIN1 | |
| SCHEMBL8022132 | 0.72 | AVPR1B (0.68) | AVPR1B | |
| SCHEMBL4315003 | 0.72 | EPHX2 (0.38) | GPR119EPHX2 | |
| SCHEMBL4310038 | 0.70 | AVPR1B (0.68) | AVPR1B | |
| SCHEMBL4302954 | 0.69 | AVPR1B (0.53) | AVPR1BGPR119EPHX2 | |
| SCHEMBL4311767 | 0.68 | TNKS (0.44) | TNKSPARP1TNKS2GRIN1GRIN2B | |
| SCHEMBL4282720 | 0.67 | GPR119 (0.45) | GPR119CACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130232-A1 | PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |