Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 7/20 | 0.37 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28427156 | 1.00 | PTGER2 (0.41) | PTGER2IGF1RHMOX1MEN1KMT2A | |
| SCHEMBL3838782 | 0.98 | PTGER2 (0.39) | PTGER2IGF1RHMOX1MEN1KMT2A | |
| SCHEMBL4451882 | 0.94 | HMOX1 (0.44) | PTGER2IGF1RHMOX1MEN1KMT2A | |
| SCHEMBL16070602 | 0.92 | IGF1R (0.39) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL3838209 | 0.92 | IGF1R (0.39) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL30096318 | 0.92 | IGF1R (0.41) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL16070705 | 0.85 | IGF1R (0.40) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL16070654 | 0.85 | IGF1R (0.40) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL3175979 | 0.85 | IGF1R (0.40) | IGF1RHMOX1MEN1KMT2ASLC18A3 | |
| SCHEMBL1986354 | 0.83 | IGF1R (0.43) | IGF1RHMOX1MEN1KMT2ASLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560597-B2 | 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2009-07-14 | — | — | US | disclosed |
| US-7560597-B2 | 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2009-07-14 | — | — | US | disclosed |
| US-7560597-B2 | 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2009-07-14 | — | — | US | disclosed |
| US-20080221220-A1 | 2',4'-DICHLORO-BIPHENYL-4-YL-HYDROXY-KETONES AND RELATED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2008-09-11 | — | — | US | disclosed |
| US-20080221220-A1 | 2',4'-DICHLORO-BIPHENYL-4-YL-HYDROXY-KETONES AND RELATED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2008-09-11 | — | — | US | disclosed |
| US-20080221220-A1 | 2',4'-DICHLORO-BIPHENYL-4-YL-HYDROXY-KETONES AND RELATED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221220-A1 | 2',4'-DICHLORO-BIPHENYL-4-YL-HYDROXY-KETONES AND RELATED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | RORB, RORC, NR1H2 | PTGER2 1682/4885IGF1R 3429/4885HMOX1 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.