Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329134 | 1.00 | MGAM (0.53) | MGAMCNR2MMP2PFKFB3KDM4E | |
| SCHEMBL1285735 | 0.88 | BACE1 (0.56) | MGAMCNR2MMP2KDM4EALDH1A1 | |
| SCHEMBL12458277 | 0.83 | MGAM (0.53) | MGAMCNR2KDM4EALDH1A1HPGD | |
| SCHEMBL16534498 | 0.81 | PFKFB3 (0.49) | CNR2PFKFB3KDM4EALDH1A1HPGD | |
| SCHEMBL22346775 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10MRGPRX4 | |
| SCHEMBL9441964 | 0.78 | IGFBP3 (0.44) | KDM4EALDH1A1HPGDHSD17B10MRGPRX4 | |
| SCHEMBL2904601 | 0.78 | IGFBP3 (0.50) | KDM4EALDH1A1HPGDHSD17B10PIM1 | |
| SCHEMBL12405037 | 0.77 | MGAM (0.63) | MGAMCNR2KDM4EALDH1A1HPGD | |
| SCHEMBL7170725 | 0.77 | MGAM (0.58) | MGAMCNR2KDM4EALDH1A1HPGD | |
| SCHEMBL26302244 | 0.76 | MGAM (0.43) | MGAMCNR2KDM4EMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | claimed |
| US-4389403-A | HYPOTENSIVE AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-06-21 | — | — | US | disclosed |
| EP-0037471-A1 | 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |