SCHEMBL4308247

SCHEMBL4308247

Clc1nc(Cl)nc(OCC2CO2)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.41
ALDH1A1 P00352 8/20 0.40
TSHR P16473 6/20 0.40
TP53 P04637 3/20 0.40
HIF1A Q16665 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP3A4 P08684 1/20 0.40
GLA P06280 1/20 0.38
MAPT P10636 2/20 0.36
HPGD P15428 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
PKM P14618 2/20 0.36
CYP1A2 P05177 1/20 0.36
PPARG P37231 1/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
ALOX15 P16050 1/20 0.32
MAPK1 P28482 1/20 0.31
FGFR1 P11362 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL48796 0.96 TDP1 (0.41) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL9174762 0.88 ALDH1A1 (0.40) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL29397562 0.85 TDP1 (0.48) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL487480 0.85 TDP1 (0.48) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL29398866 0.85 TDP1 (0.48) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL49542 0.82 SMN1; SMN2 (0.47) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL9023526 0.80 NPC1 (0.40) ALDH1A1SMN1; SMN2LMNA
SCHEMBL259402 0.78 HSP90AA1 (0.39) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL9073833 0.78 HSP90AA1 (0.55) TDP1ALDH1A1TSHRTP53HIF1A
SCHEMBL16880542 0.78 TDP1 (0.42) TDP1ALDH1A1TSHRTP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1423372-B1 TRIAZINE COMPOUNDS, POLYMERS COMPRISING TRIAZINE STRUCTURAL UNITS, AND PROCESSES FOR THE PREPARATION OF THESE POLYMERS SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-07-20 EP disclosed
US-7547749-B2 Triazine compounds, polymers comprising triazine structural units, and method SABIC INNOVATIVE PLATICS IP B.V. (NL) 2009-06-16 US disclosed
US-20080097040-A1 TRIAZINE COMPOUNDS, POLYMERS COMPRISING TRIAZINE STRUCTURAL UNITS, AND METHOD GENERAL ELECTRIC COMPANY (US) 2008-04-24 US disclosed
US-7235611-B2 Triazine compounds, polymers comprising triazine structural units, and method GENERAL ELECTRIC COMPANY (US) 2007-06-26 US disclosed
US-20050192411-A1 Triazine compounds, polymers comprising triazine structural units, and method GENERAL ELECTRIC CO. 2005-09-01 US disclosed
EP-1423372-A2 TRIAZINE COMPOUNDS, POLYMERS COMPRISING TRIAZINE STRUCTURAL UNITS, AND PROCESSES FOR THE PREPARATION OF THESE POLYMERS GENERAL ELECTRIC COMPANY (US) 2004-06-02 EP disclosed
US-20030078347-A1 Triazine compounds, polymers comprising triazine structural units, and method GENERAL ELECTRIC COMPANY 2003-04-24 US disclosed
WO-2003024939-A2 TRIAZINE COMPOUNDS POLYMERS COMPRISING TRIAZINE STRUCTURAL UNITS, AND PROCESSES FOR THE PREPARATION OF THESE POLYMERS GENERAL ELECTRIC COMPANY (US) 2003-03-27 WO disclosed
EP-0347828-B1 Compositions comprising polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GEN ELECTRIC (US) 1995-05-24 EP disclosed
EP-0347827-B1 Epoxytriazine-capped polyphenylene ethers and method of preparation GEN ELECTRIC (US) 1994-09-28 EP disclosed
US-5068286-A Molding materials, epoxychlorotriazines as end capping agents GE PLASTICS JAPAN LTD. (JP) 1991-11-26 US disclosed
US-5041504-A Engineering thermoplastics GENERAL ELECTRIC COMPANY (US) 1991-08-20 US disclosed
US-4980415-A Compositions comprising polyphenylene ethers and reactive graft polymers GENERAL ELECTRIC COMPANY (US) 1990-12-25 US disclosed
EP-0395993-A2 Compositions comprising polyphenylene ethers and reactive graft polymers GENERAL ELECTRIC COMPANY (US) 1990-11-07 EP disclosed
EP-0374517-A2 Polyphenylene ether-polyamide copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1990-06-27 EP disclosed
US-4895945-A Epoxidized chlorotriazine compounds GENERAL ELECTRIC COMPANY (US) 1990-01-23 US disclosed
EP-0349717-A2 Polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1990-01-10 EP disclosed
EP-0347827-A2 Epoxytriazine-capped polyphenylene ethers and method of preparation GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed
EP-0347539-A2 Epoxytriazine-capped polyphenylene ethers and method for their preparation GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed
EP-0347828-A2 Compositions comprising polyphenylene ether-polyester copolymers from epoxytriazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1989-12-27 EP disclosed