SCHEMBL4308949

SCHEMBL4308949

CCCCCCCCCCCCCCCCCC(=O)N1CCN(Cc2ccccc2)C(C)C1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 1/20 0.49
SIGMAR1 Q99720 1/20 0.46
ABL1 P00519 1/20 0.44
RIN1 Q13671 1/20 0.44
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
S1PR5 Q9H228 1/20 0.44
EPHX2 P34913 1/20 0.44
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
GNAI3 P08754 1/20 0.43
GNAI1 P63096 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4307522 1.00 CHRM1 (0.49) CHRM1SIGMAR1ABL1RIN1HPGD
SCHEMBL4301970 0.93 HPGD (0.48) SIGMAR1ABL1RIN1HPGDSMN1; SMN2
SCHEMBL4301981 0.93 HPGD (0.48) SIGMAR1ABL1RIN1HPGDSMN1; SMN2
SCHEMBL4301863 0.87 SIGMAR1 (0.48) SIGMAR1ABL1RIN1HPGDEPHX2
SCHEMBL4305129 0.87 SIGMAR1 (0.48) SIGMAR1ABL1RIN1HPGDEPHX2
SCHEMBL4308322 0.81 GNAI3 (0.53) CHRM1MAPTGNAI3GNAI1
SCHEMBL3322121 0.81 CHRM1 (0.55) CHRM1LMNAMAPT
SCHEMBL4306408 0.81 GNAI3 (0.53) CHRM1MAPTGNAI3GNAI1
SCHEMBL4304325 0.81 GNAI3 (0.53) CHRM1MAPTGNAI3GNAI1
SCHEMBL4308311 0.81 GNAI3 (0.53) CHRM1MAPTGNAI3GNAI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054398-A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER Korea Research Institute of Bioscience and Biotechnology (KR) 2009-05-06 EP claimed
WO-2008018778-A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2008-02-14 WO claimed
EP-2054398-A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER Korea Research Institute of Bioscience and Biotechnology (KR) 2009-05-06 EP disclosed
WO-2008018778-A1 NEW HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2008-02-14 WO disclosed